BDBM179802 3-(1-(2,6-dichloro-3-fluorophenyl)cyclopropyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridine (10)

SMILES Fc1ccc(Cl)c(c1Cl)C1(CC1)c1n[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1

InChI Key InChIKey=LQNBQZBDXDIOSM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 179802   

TargetIsoform 2 of Hepatocyte growth factor receptor (2)(Homo sapiens (Human))
Tianjin University of Science and Technology

LigandPNGBDBM179802(3-(1-(2,6-dichloro-3-fluorophenyl)cyclopropyl)-5-(...)
Affinity DataIC50:  47.4nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Tianjin University of Science and Technology

LigandPNGBDBM179802(3-(1-(2,6-dichloro-3-fluorophenyl)cyclopropyl)-5-(...)
Affinity DataIC50:  735nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor [C1156Y](Homo sapiens (Human))
Tianjin University of Science and Technology

LigandPNGBDBM179802(3-(1-(2,6-dichloro-3-fluorophenyl)cyclopropyl)-5-(...)
Affinity DataIC50:  2.99E+3nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University of Science and Technology

LigandPNGBDBM179802(3-(1-(2,6-dichloro-3-fluorophenyl)cyclopropyl)-5-(...)
Affinity DataIC50:  508nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed