BDBM179804 3-{[1-(2,6-dichloro-3-fluorophenyl)ethyl]sulfanyl}-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine (11b)

SMILES CC(Sc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl

InChI Key InChIKey=FERXSPCVEYOEDT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 179804   

TargetIsoform 2 of Hepatocyte growth factor receptor (2)(Homo sapiens (Human))
Tianjin University of Science and Technology

LigandPNGBDBM179804(3-{[1-(2,6-dichloro-3-fluorophenyl)ethyl]sulfanyl}...)
Affinity DataIC50:  51.2nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Tianjin University of Science and Technology

LigandPNGBDBM179804(3-{[1-(2,6-dichloro-3-fluorophenyl)ethyl]sulfanyl}...)
Affinity DataIC50:  2.81E+3nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor [C1156Y](Homo sapiens (Human))
Tianjin University of Science and Technology

LigandPNGBDBM179804(3-{[1-(2,6-dichloro-3-fluorophenyl)ethyl]sulfanyl}...)
Affinity DataIC50:  2.10E+3nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University of Science and Technology

LigandPNGBDBM179804(3-{[1-(2,6-dichloro-3-fluorophenyl)ethyl]sulfanyl}...)
Affinity DataIC50:  372nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed