BDBM180012 US9133148, 9c

SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CCOCC2)C(F)(F)F)CC1)C(F)(F)F

InChI Key InChIKey=PWLAAZKVHADBOS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 180012   

TargetFatty-acid amide hydrolase 1(Mus musculus (mouse))
The Scripps Research Institute

US Patent
LigandPNGBDBM180012(US9133148, 9c)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 uL, 1.0 mg/mL total protein concentration) were preincubated with varying concentration...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180012(US9133148, 9c)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of ABHD6 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180012(US9133148, 9c)
Affinity DataIC50:  25nMAssay Description:Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180012(US9133148, 9c)
Affinity DataIC50:  59nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed