BDBM18207 (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one::US10869929, Compound Dexamethasone::US11554172, Compound Dexamethasone::dexamethasone::dexamethasone (tetramethyl-rhodamine conjugated )
SMILES [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
InChI Key InChIKey=UREBDLICKHMUKA-CXSFZGCWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 18207
Affinity DataIC50: 12.6nMAssay Description:Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.98nMAssay Description:Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activityMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of fluorescent-labeled Dexamethasone binding to GRChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Agonist activity at GR assessed as NF-kappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cellsChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Activity at GR assessed as ability to antagonize dexamethasone-induced MMTV luciferase reporter gene transactivation in human A549 cellsChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to DexamethasoneChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Binding affinity to glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
Affinity DataEC50: 9.70nMAssay Description:Inhibition of glucocorticoid receptor in human H13 cells assessed as inhibition of glucocorticoid-induced cell proliferation after 3 hrs by [3H]-thym...More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Displacement of [3H]-dexamethasone human glucocorticoid receptor alpha expressed in 293 MSR cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 3.70nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.01nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.17nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexametha...More data for this Ligand-Target Pair
Affinity DataIC50: 7.94nMAssay Description:Displacement of fluorescent labeled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair