BDBM18257 5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::Pyrrolo[2, 3-d]pyrimidine analogue, 15

SMILES CCc1c(Sc2ccccc2)[nH]c2nc(N)nc(N)c12

InChI Key InChIKey=RXOBRUQVLQRTDA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 18257   

TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

LigandPNGBDBM18257(5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  170nMpH: 7.4 T: 2°CAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM18257(5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  1.80E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandPNGBDBM18257(5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  2.18E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18257(5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of rat liver DHFR using dihydrofolic acid substrate and NADPH cofactorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

LigandPNGBDBM18257(5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  880nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18257(5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  5.60E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM18257(5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  180nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed