BDBM182732 US9145408, 405
SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(C([O-])=O)c1=O
InChI Key InChIKey=OWAGGONYNCKXDC-PCXLCNFCSA-M
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 182732
Affinity DataKi: 1.10nM ΔG°: -11.4kcal/molepH: 7.4 T: 2°CAssay Description:ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...More data for this Ligand-Target Pair
Affinity DataKi: 61.6nM ΔG°: -9.83kcal/molepH: 7.4 T: 2°CAssay Description:mu-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement binding assays for mu-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN,...More data for this Ligand-Target Pair
Affinity DataKi: 75.4nM ΔG°: -9.03kcal/molepH: 7.4 T: 2°CAssay Description:Alpha-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned i...More data for this Ligand-Target Pair
Affinity DataKi: 691nM ΔG°: -8.40kcal/molepH: 7.4 T: 2°CAssay Description:Beta-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 ug m...More data for this Ligand-Target Pair
Affinity DataEC50: 0.550nMpH: 7.4 T: 2°CAssay Description:ORL-1 Receptor [35S]GTPγS Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (...More data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+4nMpH: 7.4 T: 2°CAssay Description:Mu-Opioid Receptor Functional Assay Procedures: [35S]GTP gamma S functional assays were conducted using freshly thawed mu-receptor membranes. Assay r...More data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+4nMpH: 7.4 T: 2°CAssay Description:Alpha-Opioid Receptor Functional Assay Procedures: Functional [35S]GTPgammaS binding assays were conducted as follows. Kappa opioid receptor membrane...More data for this Ligand-Target Pair