BDBM18692 (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorobenzene)sulfonyl]-2-hydroxy-2-methylpropanamide::(S)-Bicalutamide::CHEMBL124881

SMILES C[C@@](O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=LKJPYSCBVHEWIU-QGZVFWFLSA-N

Data  3 KI  3 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 18692   

TargetAndrogen receptor(Rattus norvegicus (Rat))
Csc-Scientific Computing

Curated by ChEMBL
LigandPNGBDBM18692((2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataKi:  363nMAssay Description:Inhibition of [3H]mibolerone binding to cytosolic androgen receptor of rat ventral prostateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM18692((2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataKi:  365nMAssay Description:Binding affinity to Androgen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
Csc-Scientific Computing

Curated by ChEMBL
LigandPNGBDBM18692((2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataKi:  365nM ΔG°:  -8.16kcal/molepH: 7.4 T: 2°CAssay Description:The Ki values were determined by the application of the Cheng-Prusoff equation: Ki = (IC50 x Kd)/(Kd+[L]) where [L] is the concentration of [3H]MIB (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM18692((2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM18692((2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  270nMAssay Description:Inhibition of androgen receptor in human LNCAP cells after 1 day by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM18692((2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataEC50:  31nMAssay Description:Displacement of [3H]R1881 from AR in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM18692((2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  300nMAssay Description:Antagonist activity at human androgen receptor expressed in human CV1 cells assessed as inhibition of receptor-mediated transactivation by MMTV-lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM18692((2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataEC50:  1.40E+3nMAssay Description:Displacement of [3H]R1881 from AR in human LNCaP cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed