BDBM18207 (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one::US10869929, Compound Dexamethasone::US11554172, Compound Dexamethasone::dexamethasone::dexamethasone (tetramethyl-rhodamine conjugated )
SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
InChI Key InChIKey=UREBDLICKHMUKA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 180 hits for monomerid = 18207
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at recombinant human glucocorticoid receptor expressed in African green monkey CV1 cells by MMTV luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nM ΔG°: -11.0kcal/mole IC50: 1.40nM EC50: 0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
Affinity DataKi: 0.360nMAssay Description:Displacement of [3H]-aldosterone from human mineralocorticoid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Agonist activity at glucocorticoid receptor in human foreskin fibroblasts assessed as inhibition of IL-1-induced IL-6 production by trans-repression ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.508nMAssay Description:Antagonist activity at glucocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity a...More data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL1-induced IL-6 production after 18 to 24 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataKi: 0.690nMAssay Description:Displacement of [3H]-dexamethasone from human glucocorticoid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 productionMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Activity at glucocorticoid receptor in human A549 cells assessed as effect on GRE promoter response by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Effective agonist concentration for transcriptional repression of IL-6 production in IL-1 stimulated human foreskin fibroblastsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of IL-1beta-induced NF-kappaB dependent E-selectin activation ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as E-selectin transrepression by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Transrepression activity of glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin tr...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity to glucocorticoid receptor-LBD (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Transrepression activity at glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin tr...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Transrepression activity at GR in IL-1-beta-stimulated human A549 cells assessed as inhibition of NF-kappaB-dependent E-selectin transcription by luc...More data for this Ligand-Target Pair
Affinity DataIC50: 1.17nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Agonist activity at GR assessed as NF-kappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at human GCR expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Binding affinity to human glucocorticoid receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.58nMAssay Description:Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human HeLa cells assessed as inhibition of TPA-induced coll...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Transactivation activity at glucocorticoid receptor in human HeLa cells assessed as induction of MMTV promoter activity by luciferase reporter gene a...More data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Transactivation activity of glucocorticoid receptor in HFF assessed as induction of aromatase activity by measuring beta-estradiol activity after 18 ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by EL...More data for this Ligand-Target Pair
Affinity DataKd: 2nMAssay Description:Binding affinity to GR (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with 3XGRE-promoter luciferase plasmid construct assessed as induct...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:HUT78 cells were cultured in IMEM plus 20% heat inactivated FBS and cell density was maintained between 0.1 to 1.2 million/mL. 786-O cells were cultu...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:The potency of binding to gucocorticoid receptor by small molecule compounds was measured with the PolarScreen Glucocorticoid Receptor Competitor Ass...More data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]Dexamethasone from glucocorticoid receptor in human HeLaS3 cells after 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Agonist activity at GAL4 DNA-binding domain fused GR (unknown origin) ligand binding domain expressed in UAS-bla HEK 293T cells assessed as beta-lact...More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activation by luciferase reporter gene ass...More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene act...More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Transrepression of glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activity by luciferase reporter gene assayMore data for this Ligand-Target Pair