BDBM19023 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Apixaban::BMS-562247::CHEMBL231779::US9938272, Example Apixaban
SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O
InChI Key InChIKey=QNZCBYKSOIHPEH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 19023
Affinity DataKi: 0.0750nM ΔG°: -13.8kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition of peptide substrate cleavage by FXa was assayed against six concentrations of S2765 and six concentrations of apixaban. Typical assays we...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.0800nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Binding affinity to human coagulation factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of purified human factor XaMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nM ΔG°: -13.7kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition of peptide substrate cleavage by FXa was assayed against six concentrations of S2765 and six concentrations of apixaban. Typical assays we...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nM ΔG°: -13.6kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition of peptide substrate cleavage by FXa was assayed against six concentrations of S2765 and six concentrations of apixaban. Typical assays we...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nM ΔG°: -13.6kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition of peptide substrate cleavage by FXa was assayed against six concentrations of S2765 and six concentrations of apixaban. Typical assays we...More data for this Ligand-Target Pair
Affinity DataKi: 0.410nM ΔG°: -12.8kcal/molepH: 7.5 T: 2°CAssay Description:For comparison with the prothrombinase reaction the assays were also conducted with S2765 at 25 and 37°C in a similar buffer: 20 mM HEPES, pH 7.5 con...More data for this Ligand-Target Pair
Affinity DataKi: 0.720nM ΔG°: -13.0kcal/molepH: 7.5 T: 2°CAssay Description:For comparison with the prothrombinase reaction the assays were also conducted with S2765 at 25 and 37°C in a similar buffer: 20 mM HEPES, pH 7.5 con...More data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human factor 2aMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair