BDBM190878 US9670203, Compound 1.75 1-(2-methoxypyridin-4-yl)-3-((1S,1aS,6bS)-5-((7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-yl)urea

SMILES COc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccn1

InChI Key InChIKey=SZUXBHKEGDXWEA-FKBYEOEOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 190878   

LigandPNGBDBM190878(US9670203, Compound 1.75 1-(2-methoxypyridin-4-yl)...)
Affinity DataIC50:  270nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM190878(US9670203, Compound 1.75 1-(2-methoxypyridin-4-yl)...)
Affinity DataIC50:  2.20E+3nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent