BDBM19152 (1S,7R,10S,16E,21R)-21-methyl-7-(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone::FK228 Analogue, 8a

SMILES CC(C)[C@H]1NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C)C(=O)N2)OC(=O)CNC1=O

InChI Key InChIKey=HSJYBAMFGRGVOF-OIFMFDPVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19152   

TargetHistone deacetylase 1(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM19152((1S,7R,10S,16E,21R)-21-methyl-7-(propan-2-yl)-2-ox...)
Affinity DataIC50:  1.60nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
University of Southampton

LigandPNGBDBM19152((1S,7R,10S,16E,21R)-21-methyl-7-(propan-2-yl)-2-ox...)
Affinity DataIC50:  881nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed