BDBM191769 US11608309, Compound 6::US9187406, Compound 6

SMILES COc1cc(\C=C\C(=O)C(C(=O)Nc2ccccc2)C(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O

InChI Key InChIKey=XOWCANZIJBUHCZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 191769   

TargetCollagenase 3(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191769(US9187406, Compound 6 | US11608309, Compound 6)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:The synthetic octapeptide substrate, containing the collagenase-susceptible glycine-isoleucine peptide bond, was incubated (37° C.) with commerci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetCollagenase 3(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191769(US9187406, Compound 6 | US11608309, Compound 6)
Affinity DataIC50: 1.00E+3nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent

Target72 kDa type IV collagenase (MMP2)(Human)
The State University of New York

US Patent
LigandPNGBDBM191769(US9187406, Compound 6 | US11608309, Compound 6)
Affinity DataIC50: 8.50E+4nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent

Target72 kDa type IV collagenase (MMP2)(Human)
The State University of New York

US Patent
LigandPNGBDBM191769(US9187406, Compound 6 | US11608309, Compound 6)
Affinity DataIC50: 8.50E+4nMT: 2°CAssay Description:The synthetic octapeptide substrate, containing the collagenase-susceptible glycine-isoleucine peptide bond, was incubated (37° C.) with commerci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent