BDBM192503 US9187474, 18

SMILES CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)ccc1F

InChI Key InChIKey=ACGNJFZSGIKELN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 192503   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM192503(US9187474, 18)
Affinity DataIC50:  35nMAssay Description:Sample preparation: A375 cells from ATCC are lysed by sonication in commercially available lysis buffer, cleared by centrifugation, and the resulting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM192503(US9187474, 18)
Affinity DataIC50:  20nMAssay Description:Sample preparation: A375 cells from ATCC are lysed by sonication in commercially available lysis buffer, cleared by centrifugation, and the resulting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase A-Raf(Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM192503(US9187474, 18)
Affinity DataIC50:  31nMAssay Description:Sample preparation: A375 cells from ATCC are lysed by sonication in commercially available lysis buffer, cleared by centrifugation, and the resulting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM192503(US9187474, 18)
Affinity DataIC50:  37nMAssay Description:Sample preparation: A375 cells from ATCC are lysed by sonication in commercially available lysis buffer, cleared by centrifugation, and the resulting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent