BDBM192574 US9187486, 37::US9187486, 39::US9187486, 60

SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F

InChI Key InChIKey=BYFQNMWZRKKFRI-CABCVRRESA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 192574   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  0.100nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  2.10nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  0.100nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  0.200nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  7.80nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of radiolabeled dofetilide binding to human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  0.0940nMAssay Description:Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  0.0240nMAssay Description:Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  0.0270nMAssay Description:Inhibition of Pim3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1/pim-2/pim-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  28nMAssay Description:Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM192574(US9187486, 37 | US9187486, 39 | US9187486, 60)
Affinity DataIC50:  0.300nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In DepthDetails US Patent