BDBM193245 US9193736, 169

SMILES OC(=O)CCc1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)[C@H]1C[C@@H](C1)c1ccc2ccccc2n1

InChI Key InChIKey=LDCUXBYGYWRBTO-SOAUALDESA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 193245   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL

LigandBDBM193245(US9193736, 169)Copy SMILESCopy InChI

Affinity DataIC50:  2.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetIsoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent

LigandBDBM193245(US9193736, 169)Copy SMILESCopy InChI

Affinity DataIC50:  2nMAssay Description:Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI