BDBM19410 CHEMBL27759::MS-275::US11377423, MS-275::US11672788, Compound Entinostat::US9265734, MS-275::US9796664, Compound MS-275::benzamide-type inhibitor, 3::pyridin-3-ylmethyl N-({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate

SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1

InChI Key InChIKey=INVTYAOGFAGBOE-UHFFFAOYSA-N

Data  10 KI  259 IC50  2 Kd  2 EC50  3 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 19410   

TargetHistone deacetylase 1(Homo sapiens (Human))
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  3.20E+3nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  720nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  590nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  3.20E+3nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  720nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  590nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
In DepthDetails US Patent