BDBM194794 US9206167, 15::USRE48059, Compound of Example 15

SMILES O=C1CCc2ccc(OC\C=C\CN3CCN(CC3)c3cccc4sccc34)cc2N1

InChI Key InChIKey=PFDUTSYNBVBRFL-OWOJBTEDSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 194794   

TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM194794(US9206167, 15 | USRE48059, Compound of Example 15)
Affinity DataKi:  0.200nMAssay Description:Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM194794(US9206167, 15 | USRE48059, Compound of Example 15)
Affinity DataKi:  0.200nM ΔG°:  -13.2kcal/molepH: 7.4 T: 2°CAssay Description:The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM194794(US9206167, 15 | USRE48059, Compound of Example 15)
Affinity DataKi:  3.30nMAssay Description:5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM194794(US9206167, 15 | USRE48059, Compound of Example 15)
Affinity DataKi:  3.30nM ΔG°:  -12.0kcal/molepH: 7.4 T: 2°CAssay Description:The assay was performed according to the method by Leysen J E et al. (Leysen J E, Niemegeers C J E, Van Nueten J M and Laduron P M. [3H] Ketanserin (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent