BDBM195864 US9670213, Compound 009 4-(dimethylamino)-N-(4-(2-(4-methoxyphenylamino)-7-oxo-8(7H)-pteridin-yl)phenyl)-2-buteneamide
SMILES COc1ccc(Nc2ncc3ncc(=O)n(-c4ccc(NC(=O)\C=C\CN(C)C)cc4)c3n2)cc1
InChI Key InChIKey=ZVPLRCNYKVNOMV-SNAWJCMRSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 195864
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 11nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 61nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 81nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 39nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University Of Science & Technology
Curated by ChEMBL
East China University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 184nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 (564 to 993 residues) expressed in baculovirus expression system using peptide FAM-P2 as substrate inc...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University Of Science & Technology
Curated by ChEMBL
East China University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 152nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science & Technology
Curated by ChEMBL
East China University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 59nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science & Technology
Curated by ChEMBL
East China University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 5.31E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair