BDBM1961 (Alkylamino)piperidine BHAP Analog 17::1-[(5-Methanesulfonamidoindol-2-yl)carbonyl]-4-[N-ethyl-N-[3-(ethylamino)-2-pyridinyl]amino]piperidine::CHEMBL127283::N-{2-[(4-{ethyl[3-(ethylamino)pyridin-2-yl]amino}piperidin-1-yl)carbonyl]-1H-indol-5-yl}methanesulfonamide

SMILES CCNc1cccnc1N(CC)C1CCN(CC1)C(=O)c1cc2cc(NS(C)(=O)=O)ccc2[nH]1

InChI Key InChIKey=JHLMUSUWOQINSF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 1961   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1961((Alkylamino)piperidine BHAP Analog 17 | 1-[(5-Meth...)
Affinity DataIC50:  460nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1961((Alkylamino)piperidine BHAP Analog 17 | 1-[(5-Meth...)
Affinity DataIC50:  540nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM1961((Alkylamino)piperidine BHAP Analog 17 | 1-[(5-Meth...)
Affinity DataIC50:  390nMAssay Description:Inhibition of Reverse transcriptase (Y181C) using poly(rA)600:oligo(dT)10 as template primer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM1961((Alkylamino)piperidine BHAP Analog 17 | 1-[(5-Meth...)
Affinity DataIC50:  430nMAssay Description:Inhibition of Reverse transcriptase (Wild Type) with poly(rA)600:oligo(dT)10 template primerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM1961((Alkylamino)piperidine BHAP Analog 17 | 1-[(5-Meth...)
Affinity DataIC50:  360nMAssay Description:Inhibition of Reverse transcriptase (P236L) using poly(rA)600:oligo(dT)10 as template primer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1961((Alkylamino)piperidine BHAP Analog 17 | 1-[(5-Meth...)
Affinity DataIC50:  880nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed