BDBM196822 US9212186, 18::US9212186, 19::US9212186, 20::US9212186, 21

SMILES CNc1nc(Nc2cnn3CC(C)OC(C)c23)ncc1C(F)(F)F

InChI Key InChIKey=HVPGKPCGQMAXGL-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 196822   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM196822(US9212186, 18 | US9212186, 19 | US9212186, 20 | US...)
Affinity DataKi:  1.80nMAssay Description:This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM196822(US9212186, 18 | US9212186, 19 | US9212186, 20 | US...)
Affinity DataKi:  5.70nMAssay Description:This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM196822(US9212186, 18 | US9212186, 19 | US9212186, 20 | US...)
Affinity DataKi:  61.3nMAssay Description:This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM196822(US9212186, 18 | US9212186, 19 | US9212186, 20 | US...)
Affinity DataKi:  390nMAssay Description:This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent