BDBM19760 (2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-2-[1-(4-phenylpiperidin-1-yl)acetamido]pentanamide::dipeptidyl nitrile, 16a

SMILES CC(C)C[C@H](NC(=O)CN1CCC(CC1)c1ccccc1)C(=O)N[C@@H](COCc1ccccc1)C#N

InChI Key InChIKey=IVVYCBBKQYBPIG-SXOMAYOGSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19760   

TargetCathepsin K(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19760((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50:  83nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19760((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50:  140nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19760((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50:  1.20E+3nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed