BDBM19993 CHEMBL62136::N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide::T 0901317::T0901317::TO-901317::US10543183, Compound TO901317::US10669296, Compound TO901317::US10945978, Compound 1::[3H]T0901317
SMILES c1ccc(cc1)S(=O)(=O)[N@@](CC(F)(F)F)c2ccc(cc2)C(C(F)(F)F)(C(F)(F)F)O
InChI Key InChIKey=SGIWFELWJPNFDH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 179 hits for monomerid = 19993
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 10nM EC50: 16nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
Affinity DataEC50: 55nMpH: 7.5 T: 2°CAssay Description:The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...More data for this Ligand-Target Pair
Affinity DataEC50: 30nMpH: 7.5 T: 2°CAssay Description:The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...More data for this Ligand-Target Pair
Affinity DataEC50: 60nMpH: 7.5 T: 2°CAssay Description:The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of North Carolina At Chapel Hill
University of North Carolina At Chapel Hill
Affinity DataIC50: 40nM EC50: 13nMpH: 8.0 T: 2°CAssay Description:Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMpH: 7.0 T: 2°CAssay Description:The alpha-glucosidase inhibitory activity of test compounds was determined in a 96-well plate format. The reaction mixture containing enzyme and chro...More data for this Ligand-Target Pair
Affinity DataIC50: 9nM EC50: 170nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
Affinity DataIC50: 13nM EC50: 140nMAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Polyhistidine-tagged human LXR ligand-binding domain was mixed with the test compound, biotin-SRC1 peptide, streptavidin-allophycocyanin, and europiu...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Polyhistidine-tagged human LXR ligand-binding domain was mixed with the test compound, biotin-SRC1 peptide, streptavidin-allophycocyanin, and europiu...More data for this Ligand-Target Pair
Affinity DataIC50: 9nM EC50: 16nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing ass...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing ass...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing ass...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing ass...More data for this Ligand-Target Pair
Affinity DataEC50: 800nMAssay Description:Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferas...More data for this Ligand-Target Pair
Affinity DataEC50: 940nMAssay Description:Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo lucifera...More data for this Ligand-Target Pair
Affinity DataEC50: 359nMAssay Description:Agonist activity at GAL4-tagged human LXRalpha assessed as receptor activation expressed in African green monkey CV1 cells by luciferase reporter gen...More data for this Ligand-Target Pair
Affinity DataEC50: 333nMAssay Description:Inverse agonist activity at Gal4-tagged human RORgammat ligand binding domain expressed in human Jurkat cells by native IL17 promoter driven lucifera...More data for this Ligand-Target Pair
Affinity DataEC50: 198nMAssay Description:Agonist activity at GAL4-tagged human LXRbeta assessed as receptor activation expressed in African green monkey CV1 cells by luciferase reporter gene...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of North Carolina At Chapel Hill
University of North Carolina At Chapel Hill
Affinity DataEC50: 8nMAssay Description:Transactivation of PXR in human HepG2 cells by receptor transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human LXRalpha expressed in HEK293 cells co-expressing CMX-beta-galactosidase incubated for 16 hrs by luciferase reporter gene as...More data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Agonist activity at human LXRbeta expressed in HEK293 cells co-expressing CMX-beta-galactosidase incubated for 16 hrs by luciferase reporter gene ass...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human RORalpha1 expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human RORgamma1 expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of North Carolina At Chapel Hill
University of North Carolina At Chapel Hill
Affinity DataEC50: 120nMAssay Description:Agonist activity at VP16-fused human PXR expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.60E+3nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in Amyloid beta-42 formation LPECL assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta-40 formation LPECL assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta-38 formation by LPECL assayMore data for this Ligand-Target Pair
Affinity DataEC50: 190nMAssay Description:Agonist activity at Homo sapiens (human) LXRalpha expressed in HepG2 cells assessed as transactivation of CYP7A1 gene expression after 48 hr by lucif...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Rat)
Niigata University of Pharmacy and Applied Life Sciences
Curated by ChEMBL
Niigata University of Pharmacy and Applied Life Sciences
Curated by ChEMBL
Affinity DataEC50: 30nMAssay Description:Transactivation of rat LXRbeta expressed in HEK293FT cells measured after 14 to 18 hrs by dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of North Carolina At Chapel Hill
University of North Carolina At Chapel Hill
Affinity DataEC50: 50nMAssay Description:Agonist activity at PXR (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 530nMAssay Description:Transactivation of recombinant GAL4-fused human LXRalpha LBD (163 to 447 residues) expressed in human L02 cells measured after 24 hrs by luciferase r...More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inverse agonist activity at Gal4-fused RORgamma LBD (unknown origin) expressed in 293T cells measured after 24 hrs by dual-luciferase reporter gene a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inverse agonist activity at Gal4-fused RORalpha LBD (unknown origin) expressed in 293T cells measured after 24 hrs by dual-luciferase reporter gene a...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Agonist activity at Gal4-fused LXRalpha LBD (unknown origin) expressed in 293T cells measured after 24 hrs by dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Agonist activity at Gal4-fused FXR LBD (unknown origin) expressed in 293T cells measured after 24 hrs by dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of North Carolina At Chapel Hill
University of North Carolina At Chapel Hill
Affinity DataEC50: 15nMAssay Description:Agonist activity at His-tagged PXR-LBD/SRC-1p (unknown origin) expressed in Escherichia coli BL21(DE3) by coactivator recruitment based Alpha-screen ...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity LXRalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity LXRbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity LXRalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity LXRbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human LXR-betaMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataEC50: 0.0980nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataEC50: 0.108nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of North Carolina At Chapel Hill
University of North Carolina At Chapel Hill
Affinity DataIC50: 36nMAssay Description:Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair