BDBM200328 US9227956, 13

SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C

InChI Key InChIKey=VDRAMRAAPSBWGS-LJQANCHMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 200328   

TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200328(US9227956, 13)
Affinity DataIC50:  2.30E+3nMAssay Description:An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200328(US9227956, 13)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of PCSK9 translation in human THP-1 cells by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200328(US9227956, 13)
Affinity DataIC50:  800nMAssay Description:In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent