BDBM20132 (2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2,4,6-trifluorophenyl)carbonyl]-2,3-dihydro-1,3,4-thiadiazole::N-Acylthiadiazoline, 3-R

SMILES COc1cccc([C@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC

InChI Key InChIKey=LORGBPUOJISMFM-HSZRJFAPSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 20132   

TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20132((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...)
Affinity DataEC50:  1.60E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Gnf

LigandPNGBDBM20132((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...)
Affinity DataIC50:  66nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Gnf

LigandPNGBDBM20132((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...)
Affinity DataIC50:  5.00E+3nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Gnf

LigandPNGBDBM20132((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...)
Affinity DataEC50:  67nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed