BDBM203876 Mcl-1 inhibitor 12
SMILES CCc1nn(C)c(CC)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(O)=O)n(CCN3CCOCC3)c12
InChI Key InChIKey=NXAYYSHEARRBLR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 203876
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 1.60nM ΔG°: -12.0kcal/mole IC50: 5.96nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Affinity DataEC50: 340nMAssay Description:Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair