BDBM206287 (S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)propan-2-yl)-N4-hydroxyterephthalamide (12m)

SMILES Cc1ccc(NC(=O)[C@@H](NC(=O)c2ccc(cc2)C(=O)NO)c2c[nH]c3ccccc23)cc1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 206287   

TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)
Affinity DataIC50:  74nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)
Affinity DataIC50:  219nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)
Affinity DataIC50:  3.50E+3nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)
Affinity DataIC50: >1.00E+5nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)
Affinity DataIC50:  168nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shandong University

LigandPNGBDBM206287((S)-N1-(3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)pr...)
Affinity DataIC50:  5.50E+3nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed