BDBM206331 US9259422, 23, R = Ph-BU129::US9480684, 23, R = Ph- BU129

SMILES CO[C@]12C=C[C@@]3(C[C@]1(C)[C@@H](O)c1ccccc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45

InChI Key InChIKey=NZCUONOJSJVNOY-JJIKELEOSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 206331   

TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University of Bath

US Patent
LigandPNGBDBM206331(US9259422, 23, R = Ph-BU129 | US9480684, 23, R = P...)
Affinity DataKi:  0.600nM ΔG°:  -12.6kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University of Bath

US Patent
LigandPNGBDBM206331(US9259422, 23, R = Ph-BU129 | US9480684, 23, R = P...)
Affinity DataKi:  0.600nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University of Bath

US Patent
LigandPNGBDBM206331(US9259422, 23, R = Ph-BU129 | US9480684, 23, R = P...)
Affinity DataKi:  1.08nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University of Bath

US Patent
LigandPNGBDBM206331(US9259422, 23, R = Ph-BU129 | US9480684, 23, R = P...)
Affinity DataKi:  1.08nM ΔG°:  -12.2kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University of Bath

US Patent
LigandPNGBDBM206331(US9259422, 23, R = Ph-BU129 | US9480684, 23, R = P...)
Affinity DataKi:  3.02nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University of Bath

US Patent
LigandPNGBDBM206331(US9259422, 23, R = Ph-BU129 | US9480684, 23, R = P...)
Affinity DataKi:  3.02nM ΔG°:  -11.6kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent