BDBM207986 3-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-(4-fluorobenzyl)-5-hydroxy-1,5-dihydro-2H-furan-2-one (2c)

SMILES OC1(Cc2ccc(F)cc2)OC(=O)C(Cc2ccc(Cl)cc2)=C1c1c[nH]c2cc(Cl)ccc12

InChI Key

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 207986   

TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM207986(3-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-(4...)
Affinity DataKd:  2.87E+4nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM207986(3-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-(4...)
Affinity DataKd:  1.80E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed