BDBM209291 US9266883, 49

SMILES OCc1cc2CCCN(C(=O)Nc3cc(O[C@@H]4CCOC4)c(cn3)C#N)c2nc1C=O

InChI Key InChIKey=JDSIDNMVOWOKBD-MRXNPFEDSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 209291   

TargetFibroblast growth factor receptor 4 [388-802](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM209291(US9266883, 49)
Affinity DataIC50:  4.5nMpH: 7.5 T: 2°CAssay Description:Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM209291(US9266883, 49)
Affinity DataKd:  6nMAssay Description:Displacement of reporter probe from human recombinant FGFR4 (391 to 802) expressed in Baculovirus infected Sf9 cells measured after 30 mins by proter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM209291(US9266883, 49)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM209291(US9266883, 49)
Affinity DataIC50:  12nMAssay Description:Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM209291(US9266883, 49)
Affinity DataIC50:  22nMAssay Description:Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed