BDBM209945 US9249124, 27

SMILES OC(=O)c1ccc(Nc2nccc(Nc3ccc(F)cc3OC(F)(F)F)n2)cc1

InChI Key InChIKey=VJCIBGLXXNCKLT-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 209945   

TargetAurora kinase A(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM209945(US9249124, 27)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM209945(US9249124, 27)
Affinity DataIC50:  28nM Kd:  40nMpH: 7.4Assay Description:The binding of inhibitors to Aurora A kinase was analyzed with a MicroCal iTC200 titration calorimeter (GE Healthcare, Piscataway, N.J.). The protein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM209945(US9249124, 27)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:Aurora A was exchanged into 50 mM phosphate buffer (pH 7.4) including 1 mM DTT via PD-10 columns and was concentrated to 20 mg mL-1 using Amicon Ultr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent