BDBM209945 US9249124, 27
SMILES OC(=O)c1ccc(Nc2nccc(Nc3ccc(F)cc3OC(F)(F)F)n2)cc1
InChI Key InChIKey=VJCIBGLXXNCKLT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 209945
TargetAurora kinase A(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute
US Patent
H. Lee Moffitt Cancer Center and Research Institute
US Patent
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute
US Patent
H. Lee Moffitt Cancer Center and Research Institute
US Patent
Affinity DataIC50: 28nM Kd: 40nMpH: 7.4Assay Description:The binding of inhibitors to Aurora A kinase was analyzed with a MicroCal iTC200 titration calorimeter (GE Healthcare, Piscataway, N.J.). The protein...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute
US Patent
H. Lee Moffitt Cancer Center and Research Institute
US Patent
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Aurora A was exchanged into 50 mM phosphate buffer (pH 7.4) including 1 mM DTT via PD-10 columns and was concentrated to 20 mg mL-1 using Amicon Ultr...More data for this Ligand-Target Pair