BDBM210300 US9546153, ex. 367

SMILES CC(C)Nc1cc(Nc2nc3ccnn3cc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O

InChI Key InChIKey=SNCZIVUNTWOQAF-OAHLLOKOSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 210300   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50:  4.80nMpH: 7.2 T: 2°CAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50:  370nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50:  920nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInterleukin-1 receptor-associated kinase 3(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50:  760nMAssay Description:Inhibition of human wild type partial length IRAK3 (147 to 596 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human cKit (544 to end residues) expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of N-terminal His6-tagged human full length recombinant LCK expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50:  980nMAssay Description:Inhibition of human wild type partial length TYRO3 (497 to 814 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM210300(US9546153, ex. 367)
Affinity DataIC50:  130nMAssay Description:Inhibition of human wild type partial length TNIK (D4-K311 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed