BDBM21281 (11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphthalen-1-ylcarbonyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraene::(2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonat::CHEMBL188::WIN 55,212-2::WIN 55212-2::WIN-55212::WIN55212-2
SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23
InChI Key InChIKey=HQVHOQAKMCMIIM-HXUWFJFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 21281
Affinity DataKi: 1.30nM EC50: 125nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 50.1nMAssay Description:Agonist activity at human cannabinoid CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.470nMAssay Description:Agonist activity at human CB2 receptor expressed in CHOK1 cells assessed as reversal of forskolin-evoked cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human CB2 receptor after 1 hr by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at human CB2 receptor by GTPgamma[35S] assayMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at cloned human CB2 receptor in Sf9 cells assessed as stimulation of [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Inverse agonist activity at human CB2 receptor transfected in CHO cells assessed as increase in forksolin stimulated cAMP production by scintillation...More data for this Ligand-Target Pair
Affinity DataEC50: 1.45E+3nMAssay Description:Agonist activity at CB1 receptor in ICR mouse vas deferens assessed as inhibition of electrically-stimulated contractionMore data for this Ligand-Target Pair
Affinity DataEC50: 37nMAssay Description:Agonist activity at human recombinant CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: 0.390nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at rat CB1 receptor assessed as inhibition of forskolin-induced cAMP production by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at rat CB2 receptor assessed as inhibition of forskolin-induced cAMP production by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 86nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in HEK293 cells coexpressing Galphaq/o5 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 24.6nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 24.6nMAssay Description:Effect on [35S]GTP-gamma-S binding to human CB2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 89.6nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in CHO cells membrane by [35S]-GTPgammaS assayMore data for this Ligand-Target Pair
Affinity DataEC50: 204nMAssay Description:Activity at CB1 receptor assessed as stimulation of [35S]GTP-gamma-S binding in DBA/J2 mouse brainMore data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.76E+3nMAssay Description:Agonist activity at human CB1 receptor transfected in human U2OS cells assessed as beta-arrestin2-GFP aggregation after 40 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as forskolin-stimulated [3H]cyclic-AMP accumulation by scintillation counting ...More data for this Ligand-Target Pair
Affinity DataEC50: 37.6nMAssay Description:Displacement of [3H]WIN-55212-2 from human CB1 receptor in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 112nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293 cells assessed as [35S]GTPgamma bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 89.6nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO membranes assessed as [35S]-GTPgammaS binding after 1 hrMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cell membranes assessed as [35S]GTPgammaS binding after 1 hr by beta-counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 7.20nMAssay Description:Agonist activity at CB1 receptor (unknown origin) assessed as increase in beta-arrestin2 recruitment after 20 mins by BRET-based luciferase reporter ...More data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Agonist activity at CB1 receptor (unknown origin) assessed as increase in cAMP accumulation after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 44nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding after 60 mins by liquid sc...More data for this Ligand-Target Pair
Affinity DataEC50: 44nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding after 60 mins by liquid sc...More data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293 cells assessed as reversal of forskolin-evoked cAMP accumulationMore data for this Ligand-Target Pair