BDBM2145 1-(5-bromopyridin-2-yl)-3-{2-[3-cyano-4-(dimethylamino)-2-fluorophenyl]ethyl}thiourea::LY300046HCl Analog 31::N-[2-(3-Cyano-4-(dimethylamino)-2-fluorophenethyl)]-N-[2-(5-bromopyridyl)]thiourea::PETT deriv.

SMILES CN(C)c1ccc(CCNC(=S)Nc2ccc(Br)cn2)c(F)c1C#N

InChI Key InChIKey=ATPNNLDEQIZTCL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2145   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2145(1-(5-bromopyridin-2-yl)-3-{2-[3-cyano-4-(dimethyla...)
Affinity DataIC50:  8nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2145(1-(5-bromopyridin-2-yl)-3-{2-[3-cyano-4-(dimethyla...)
Affinity DataIC50:  110nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2145(1-(5-bromopyridin-2-yl)-3-{2-[3-cyano-4-(dimethyla...)
Affinity DataIC50:  210nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed