BDBM21494 6,8-dimethoxy-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol-3-yl]quinoline::Dihydropyrrolopyrazole, 7c

SMILES COc1cc(OC)c2nccc(-c3c4CCCn4nc3-c3cccc(C)n3)c2c1

InChI Key InChIKey=ZCTKDDFPWGHPQF-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21494   

TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21494(6,8-dimethoxy-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H...)
Affinity DataIC50:  3.81E+3nM EC50:  7.20E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed