BDBM21974 (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid::CHEMBL54976::L-tryptophan::US11021454, Compound L-trp::US9138393, L-Tryptophan::US9144538, L-Tryptophan

SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O

InChI Key InChIKey=QIVBCDIJIAJPQS-VIFPVBQESA-N

Data  2 KI  13 IC50  1 Kd  1 ITC

PDB links: 64 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21974   

TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Tennessee

Curated by ChEMBL

LigandBDBM21974((2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHE...)Copy SMILESCopy InChI

Affinity DataKi:  2.80E+6nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
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TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL

LigandBDBM21974((2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHE...)Copy SMILESCopy InChI

Affinity DataKi:  1.15E+7nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankKEGGMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedDrugBank

Copy BDB DOI