BDBM221240 US9303015, 14a::US9303015, 14b::US9303015, 14c

SMILES CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=CXEVNMJGHDDSGJ-UHFFFAOYSA-N

Data  6 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 221240   

TargetNuclear receptor ROR-gamma [258-518](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221240(US9303015, 14a | US9303015, 14b | US9303015, 14c)
Affinity DataKd:  22nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [258-518](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221240(US9303015, 14a | US9303015, 14b | US9303015, 14c)
Affinity DataKd:  34nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [258-518](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221240(US9303015, 14a | US9303015, 14b | US9303015, 14c)
Affinity DataKd:  10nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [258-518,Y502F](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221240(US9303015, 14a | US9303015, 14b | US9303015, 14c)
Affinity DataIC50:  6.00E+3nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [258-518,Y502F](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221240(US9303015, 14a | US9303015, 14b | US9303015, 14c)
Affinity DataIC50: >6.00E+3nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [258-518,Y502F](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221240(US9303015, 14a | US9303015, 14b | US9303015, 14c)
Affinity DataIC50:  700nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [258-518,Y502F](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221240(US9303015, 14a | US9303015, 14b | US9303015, 14c)
Affinity DataIC50:  2.00E+3nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [258-518,Y502F](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221240(US9303015, 14a | US9303015, 14b | US9303015, 14c)
Affinity DataIC50:  1.00E+3nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [258-518,Y502F](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221240(US9303015, 14a | US9303015, 14b | US9303015, 14c)
Affinity DataIC50:  1.10E+3nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent