BDBM22170 (2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazin-1-yl)-3-phenylpropan-2-ol::CHEMBL27646::GBR 12935 Analogue, (S)-5

SMILES O[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1

InChI Key InChIKey=GJDQYWYMCFMZIM-MHZLTWQESA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 22170   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Taiwan University

LigandPNGBDBM22170((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Affinity DataKi:  0.75nM ΔG°:  -11.6kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Taiwan University

LigandPNGBDBM22170((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Affinity DataKi:  0.75nMAssay Description:Binding affinity for dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22170((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Affinity DataKi:  230nMAssay Description:Binding affinity for serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22170((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Affinity DataKi:  230nM ΔG°:  -8.41kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed