BDBM22332 2-amino-5-hydroxyindole, 3n::ethyl 2-[(3-chlorophenyl)amino]-5-hydroxy-1H-indole-3-carboxylate

SMILES CCOC(=O)c1c(Nc2cccc(Cl)c2)[nH]c2ccc(O)cc12

InChI Key InChIKey=UWOMAHASUCHMCR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22332   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22332(2-amino-5-hydroxyindole, 3n | ethyl 2-[(3-chloroph...)
Affinity DataIC50:  300nMpH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22332(2-amino-5-hydroxyindole, 3n | ethyl 2-[(3-chloroph...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins by HPLC ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22332(2-amino-5-hydroxyindole, 3n | ethyl 2-[(3-chloroph...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production from arachidonic acid preincubated for 15 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed