BDBM22438 4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-hydrazide::4-hydroxy-N'-[(1E)-[4-(propan-2-yl)phenyl]methylidene]benzohydrazide::GSK 4716::GSK4716

SMILES CC(C)c1ccc(\C=N\NC(=O)c2ccc(O)cc2)cc1

InChI Key InChIKey=IKPPIUNQWSRCOZ-WOJGMQOQSA-N

Data  1 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 22438   

TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM22438(4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-h...)
Affinity DataEC50:  1.30E+3nMpH: 7.0 T: 2°CAssay Description:Recruitment of the RIP140 NR-box peptide to the ERRgamma ligand binding domain was assayed by FRET detection. Proteins were set up in a one to one ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM22438(4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-h...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to ERRgamma (unknown origin) at 20 degC by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTegument protein VP16(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM22438(4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-h...)
Affinity DataEC50:  273nMAssay Description:Agonist activity at Herpes simplex virus Gal4 fused VP16-LBD expressed in HEK293T cells after 20 hrs by UAS-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM22438(4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-h...)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at Gal4 fused ERRgamma-LBD (unknown origin) expressed in HEK293T cells after 20 hrs by UAS-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM22438(4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-h...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human N-terminal alphaHis-SUMO-tagged ERRgamma-LBD (229 to 458 residues) expressed in Escherichia coli BL21 gold (DE3) cells asse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed