BDBM22450 N-hydroxy-N -(4-{(2R,4S,6R)-4-phenyl-6-[(pyridin-4-ylsulfanyl)methyl]-1,3-dioxan-2-yl}phenyl)octanediamide::N-hydroxy-N'-{4-[(2R,4S,6R)-4-phenyl-6-[(pyridin-4-ylsulfanyl)methyl]-1,3-dioxan-2-yl]phenyl}octanediamide::NK308

SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)[C@H]1O[C@@H](CSc2ccncc2)C[C@H](O1)c1ccccc1

InChI Key InChIKey=YHZHZWCKPHXEEJ-DILYWTOHSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22450   

TargetHistone deacetylase 6(Homo sapiens (Human))
University of Notre Dame

LigandPNGBDBM22450(N-hydroxy-N -(4-{(2R,4S,6R)-4-phenyl-6-[(pyridin-4...)
Affinity DataKi:  28nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Notre Dame

LigandPNGBDBM22450(N-hydroxy-N -(4-{(2R,4S,6R)-4-phenyl-6-[(pyridin-4...)
Affinity DataKi:  88nM ΔG°:  -9.52kcal/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University of Notre Dame

LigandPNGBDBM22450(N-hydroxy-N -(4-{(2R,4S,6R)-4-phenyl-6-[(pyridin-4...)
Affinity DataKi:  6.10E+3nM ΔG°:  -7.04kcal/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed