BDBM22567 3H]pyrilamine::CHEMBL511::Dorantamin::Mepyramine::N-(4-methoxybenzyl)-N ,N -dimethyl-N-pyridin-2-ylethane-1,2-diamine::N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine::PYRILAMINE::Pyranisamine::[3H]mepyramine::[3H]pyrilamine
SMILES COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
InChI Key InChIKey=YECBIJXISLIIDS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 22567
Affinity DataIC50: 5.75nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 46.8nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.820nMAssay Description:Binding affinity to human histamine H1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against human Histamine H1 receptorMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0140nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
University of North Carolina At Chapel Hill
Curated by PDSP Ki Database
University of North Carolina At Chapel Hill
Curated by PDSP Ki Database
Affinity DataIC50: 34nMAssay Description:In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to human histamine H1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ releaseMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
University of North Carolina At Chapel Hill
Curated by PDSP Ki Database
University of North Carolina At Chapel Hill
Curated by PDSP Ki Database
Affinity DataIC50: 1.5nMAssay Description:Inhibition of guinea pig histamine H1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair