BDBM22735 1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione::Benzil-based compound, 13::CHEMBL193180

SMILES Fc1cc(cc(F)c1F)C(=O)C(=O)c1cc(F)c(F)c(F)c1

InChI Key InChIKey=FMFHXBPXDZLEKC-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 22735   

TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi:  47.9nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi:  259nM ΔG°:  -8.98kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi:  360nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi:  372nMAssay Description:Inhibition of human carboxylesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi:  372nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi:  470nMAssay Description:Inhibition of human carboxylesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | B...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed