BDBM227802 US10047096, 65::rac-4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-[(3-hydroxypyrrolidin-1-yl)methyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCC(O)C5)cc4NC(=O)c23)cc1O

InChI Key InChIKey=QIZGCINCAAEMBX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227802   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227802(US10047096, 65 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50:  1.05nMpH: 7.5 T: 2°CAssay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227802(US10047096, 65 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50:  0.246nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent