BDBM228113 (e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(methoxy-d3)quinazolin-6-yl)-4-((4ar,7as)-tetrahydro 2h-[1,4]dioxino[2,3-c]pyrrol-6(3h)-yl)but-2-enamide::US9556191, example 20

SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1C[C@H]2OCCO[C@H]2C1

InChI Key InChIKey=REGOTSLWVKSZRG-GYQWKJCYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 228113   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228113((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(metho...)
Affinity DataIC50:  4.80nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228113((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(metho...)
Affinity DataIC50:  12.5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228113((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(metho...)
Affinity DataIC50:  15.8nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In DepthDetails US Patent