BDBM228120 (e)-n-(4-((1-(3-fluorobenzyl)-1h-indazol-5-yl)amino)-7-methoxyquinazolin-6-yl)-4-((4ar,7as)-tetra hydro-2h-[1,4]dioxin[2,3-c]pyrrol-6(3h)-yl)but-2-enamide::US9556191, example 27

SMILES COc1cc2ncnc(Nc3ccc4n(Cc5cccc(F)c5)ncc4c3)c2cc1NC(=O)\C=C\CN1C[C@H]2OCCO[C@H]2C1

InChI Key InChIKey=XRKMXTSLBXGSQT-MYOSJQCNSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 228120   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228120((e)-n-(4-((1-(3-fluorobenzyl)-1h-indazol-5-yl)amin...)
Affinity DataIC50:  7.90nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228120((e)-n-(4-((1-(3-fluorobenzyl)-1h-indazol-5-yl)amin...)
Affinity DataIC50:  22.9nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228120((e)-n-(4-((1-(3-fluorobenzyl)-1h-indazol-5-yl)amin...)
Affinity DataIC50:  2.20nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent