BDBM229594 US9334288, 2

SMILES Cc1ccc2[nH]c(=O)c(CN(CCO)C(=O)Nc3ccccc3F)cc2c1

InChI Key InChIKey=IZEKTGGQNDYMPR-UHFFFAOYSA-N

Data  2 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 229594   

TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM229594(US9334288, 2)
Affinity DataIC50:  586nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM229594(US9334288, 2)
Affinity DataEC50:  221nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM229594(US9334288, 2)
Affinity DataIC50:  601nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM229594(US9334288, 2)
Affinity DataEC50:  233nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent