BDBM230874 US10045974, 10::US10603310, Compound 10::US9346797, 10

SMILES COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(N=C(N)CCC2(F)F)C(F)F)c(C)n1

InChI Key InChIKey=OXHGYPKMJMHUJT-IBGZPJMESA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 230874   

TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM230874(US10045974, 10 | US10603310, Compound 10 | US93467...)
Affinity DataKi:  16nM ΔG°:  -10.6kcal/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM230874(US10045974, 10 | US10603310, Compound 10 | US93467...)
Affinity DataKi:  16nMAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM230874(US10045974, 10 | US10603310, Compound 10 | US93467...)
Affinity DataKi:  16nM ΔG°:  -10.6kcal/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent