BDBM23300 4-amino-7-chloroquinoline (ACQ)-based compound, 5::7-chloroquinolin-4-amine::CHEMBL44789

SMILES Nc1ccnc2cc(Cl)ccc12

InChI Key InChIKey=NDRZSRWMMUGOBP-UHFFFAOYSA-N

Data  2 IC50  2 EC50  1 Other

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 23300   

TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
National Cancer Institute At Frederick

LigandPNGBDBM23300(4-amino-7-chloroquinoline (ACQ)-based compound, 5 ...)
Affinity DatapH: 7.3 T: 2°CAssay Description:Botox A catalyzed the hydrolysis of substrate peptide between residues 11 (glutamine) and 12 (arginine), corresponding to residues 197 and 198 of SNA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM23300(4-amino-7-chloroquinoline (ACQ)-based compound, 5 ...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 4 group A member 2(Homo sapiens (Human))
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23300(4-amino-7-chloroquinoline (ACQ)-based compound, 5 ...)
Affinity DataEC50:  2.59E+5nMAssay Description:Agonist activity at Nurr1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear receptor subfamily 4 group A member 2(Homo sapiens (Human))
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23300(4-amino-7-chloroquinoline (ACQ)-based compound, 5 ...)
Affinity DataEC50:  2.59E+5nMAssay Description:Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity incubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1/2(Homo sapiens (Human))
Roche Discovery Welwyn

Curated by ChEMBL
LigandPNGBDBM23300(4-amino-7-chloroquinoline (ACQ)-based compound, 5 ...)
Affinity DataIC50:  1.68E+5nMAssay Description:Inhibitory activity against (IMPDH) inosine 5'-monophosphate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed