BDBM23417 α-CA inhibitor, 4::(-)-Epicatechin::(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol::Epicatechin::L-Epicatechin::cid_72276

SMILES O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1

InChI Key InChIKey=PFTAWBLQPZVEMU-UKRRQHHQSA-N

Data  7 KI  24 IC50  2 Kd  3 EC50  1 Other

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23417   

TargetArginase(Leishmania amazonensis)
Universidade Federal De S£O Carlos

Curated by ChEMBL
LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Affinity DataKi:  200nMAssay Description:Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ege University

LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Affinity DataKi:  1.24E+3nMpH: 7.4Assay Description:CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Ege University

LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Affinity DataKi:  2.32E+3nMpH: 7.4Assay Description:CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Ege University

LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Affinity DataKi:  3.98E+3nMpH: 7.4Assay Description:CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Ege University

LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Affinity DataKi:  4.36E+3nMpH: 7.4Assay Description:CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 3(Bos taurus (Cattle))
Ege University

LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Affinity DataKi:  8.93E+3nMpH: 7.4Assay Description:CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article