BDBM235733 US9359371, 1
SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CC3CC3C2)cc1Cl
InChI Key InChIKey=MZTKPBZVHILACH-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 235733
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [537-875](Homo sapiens (Human))
Xuanzhu Pharma
US Patent
Xuanzhu Pharma
US Patent
Affinity DataIC50: 6.04nMpH: 7.5Assay Description:To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...More data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Xuanzhu Pharma
US Patent
Xuanzhu Pharma
US Patent
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [537-875](Homo sapiens (Human))
Xuanzhu Pharma
US Patent
Xuanzhu Pharma
US Patent
Affinity DataIC50: 6.04nMpH: 7.5Assay Description:The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...More data for this Ligand-Target Pair